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Stem Cell Related Patent Number US7118748
| Title: | Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation | | Inventors: | Rodgers, Kathleen E.; Long Beach, CA, USA
diZerega, Gere S.; Pasadena, CA, USA | | Summary: | Described herein is a method of promoting hematopoietic and mesenchymal cell proliferation and differentiation. This invention relates to contacting such cells with angiotensinogen, angiotensin I or II, or analogues or fragments thereof, either alone or in combination with other growth factors and cytokines. Improved cell culture media are also described, as are kits for promoting hematopoietic and mesenchymal stem and lineage-specific cell proliferation and differentiation. Formulations are provided which contain one or more amino acid sequences consisting of at least five contiguous amino acids of SEQ ID NO:4. Therapeutic applications in cancer treatment are included. | | Abstract: | The present invention provides methods, improved cell culture medium and kits for promoting hematopoietic and mesenchymal stem and lineage-specific cell proliferation and differentiation by growth in the presence of angiotensinogen, angiotensin I (Al), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists, either alone or in combination with other growth factors and cytokines. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US7118748 | | Application Number: | US2000000564045 | | Date Filed: | 03/05/2000 | | Date Published: | 10/10/2006 | | Assignee: | University of Southern California, Los Angeles, CA, USA |
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