Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7119071

Title:Amino terminal substance P compositions and methods for using the same
Inventors:Rameshwar, Pranela; Maplewood, NJ, USA
Summary:This invention describes a new substance-P tetrapeptide, SP(1-4) polynucleotide and encoded polypeptide, and uses thereof. Disclosed herein are methods by which the degradation of SP to SP(1-4) by endogenous NEP in bone marrow stroma can offer mediation of hematopoietic stimulation by stem cell factor (SCF), thereby inducing the production of TGF-beta and TNF-alpha in bone marrow stroma. Further described are compositions containing the SP(1-4) polypeptide, or NEP genetic elements, and applications to slowing the rapid growth of stem and progenitor cells, thereby affording protection from the deleterious effects of cancer therapy. The authors include applications of these polynucleotides and proteins to the alleviation of the toxic effects of chemotherapy and radiation treatment, as well as therapeutic applications of compositions containing NEP antisense sequences and antibodies in the increased proliferation and differentiation of stem and/or progenitor cells in patients receiving conventional chemo- and radiotherapy.
Abstract:The present invention establishes the fact that the degradation of SP to SP(1-4) by endogenous NEP in BM stroma can be a mediator of hematopoietic stimulation by stem cell factor (SCF) and induce the production of TGF-β and TNF-α in BM stroma. The present invention establishes that compositions containing the SP(1-4) polypeptide, or NEP genetic elements, can be used to slow and or stop the rapid growth of stem and progenitor cells thus protecting them from the deleterious effects of cancer therapy. Hence, the polynucleotides and proteins of the present invention may be used to protect stem cells from the toxic effects of chemo- and radio-therapy, in those undergoing, or about to undergo such cancer related treatments. Also provided are compositions containing NEP antisense sequences and antibodies used for the increased proliferation and differentiation of stem and/or progenitor cells in those whom have already undergone chemo- and/or radio-therapy.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7119071
Application Number:US2002000154332
Date Filed:21/05/2002
Date Published:10/10/2006
Assignee:University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA


 
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