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Stem Cell Related Patent Number US7132286
| Title: | Method for neural stem cell differentiation using valproate | | Inventors: | Laeng, Pascal; Washington, DC, USA | | Summary: | Herein is described a method for differentiating neural stem cells into neuronal cells, via exposure of the neural stem cells with a valproate compound or analog thereof. The invention relates to a process for differentiating a neural stem cell into a neuronal cell such as a neuroblast or neuron, in vitro or in vivo. Methods are described by which the population of mammalian neural stem cells in a medium that is free of growth factor is contacted with valproate in an amount and at a frequency of exposure sufficient to induce differentiation of the stem cells and expression of a neuronal cell marker. Therapeutic applications in the treatment of central or peripheral nervous system disorders are also discussed. | | Abstract: | The present invention relates to a method for differentiating a neural stem cell into a neuronal cell such as a neuroblast or neuron in vitro or in vivo. Particularly, the invention provides for a method for neural stem cell differentiation by contacting the neural stem cell with a valproate compound or analog thereof. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US7132286 | | Application Number: | US2002000175168 | | Date Filed: | 18/06/2002 | | Date Published: | 07/11/2006 | | Assignee: | Psychiatric Genomics, Inc., Gaithersburg, MD, USA |
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