Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7132286

Title:Method for neural stem cell differentiation using valproate
Inventors:Laeng, Pascal; Washington, DC, USA
Summary:Herein is described a method for differentiating neural stem cells into neuronal cells, via exposure of the neural stem cells with a valproate compound or analog thereof. The invention relates to a process for differentiating a neural stem cell into a neuronal cell such as a neuroblast or neuron, in vitro or in vivo. Methods are described by which the population of mammalian neural stem cells in a medium that is free of growth factor is contacted with valproate in an amount and at a frequency of exposure sufficient to induce differentiation of the stem cells and expression of a neuronal cell marker. Therapeutic applications in the treatment of central or peripheral nervous system disorders are also discussed.
Abstract:The present invention relates to a method for differentiating a neural stem cell into a neuronal cell such as a neuroblast or neuron in vitro or in vivo. Particularly, the invention provides for a method for neural stem cell differentiation by contacting the neural stem cell with a valproate compound or analog thereof.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7132286
Application Number:US2002000175168
Date Filed:18/06/2002
Date Published:07/11/2006
Assignee:Psychiatric Genomics, Inc., Gaithersburg, MD, USA


 
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