Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7138144

Title:Method of inducing immune tolerance via blood/lymph flow-restricted bone marrow transplantation
Inventors:Askenasy, Nadir; Tel Aviv, Israel
Summary:This invention describes a method of inducing tolerance to a transplant that has been transplanted from a donor to a subject. Myeloreduction or myeloablation treatment is administered to the subject, followed by a restricting of the outflow of blood and/or lymph from a portion of the circulatory system of the subject, followed by the administration of a dose of bone marrow cells derived from the donor to a body part which is delimiting that particular portion of the circulatory system. Specific mechanisms which induce greater homing of the bone marrow cells in the tissue, and which thereby induce greater tolerance of the transplant, are further disclosed.
Abstract:A method of inducing tolerance to a transplant transplanted from a donor to a subject is disclosed. The method comprises (a) restricting outflow of a fluid from a portion of the circulatory system of the subject; and (b) administering a dose of bone marrow cells derived from the donor to a body part delimiting said portion of the circulatory system, prior to, concomitantly with or following transplantation of the transplant, thereby inducing tolerance to the transplant in the subject.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7138144
Application Number:US2002000237033
Date Filed:09/09/2002
Date Published:21/11/2006
Assignee:None


 
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