Methods comprising apoptosis inhibitors for the generation of transgenic pigs |
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| Title: | Method of producing a mouse suitable for the engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse |
| Inventors: | Ito, Mamoru; Kanagawa, Japan Kobayashi, Kimio; Kanagawa, Japan Nakahata, Tatsutoshi; Kyoto, Japan Tsuji, Koichiro; Tokyo, Japan Habu, Sonoko; Tokyo, Japan Koyanagi, Yoshio; Chiba, Japan Yamamoto, Naoki; Tokyo, Japan Sugamura, Kazuo; Miyagi, Japan Ando, Kiyoshi; Kanagawa, Japan Nomura, Tatsuji; Tokyo, Japan |
| Summary: | Described herein is an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells. Further disclosed are the techniques by which such a mouse is obtained through backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor gamma-chain gene-knockout mouse with the backcrossed mouse. Therapeutic applications are included such as in the production of human antibodies and the establishment of a stem cell assay system, as well as in tumor and virus-infection models. |
| Abstract: | The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor γ-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US7145055 |
| Application Number: | US2001000221549 |
| Date Filed: | 25/10/2001 |
| Date Published: | 05/12/2006 |
| Assignee: | Central Institute for Experimental Animals, Kanagawa, Japan |