Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US7145055

Title:Method of producing a mouse suitable for the engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse
Inventors:Ito, Mamoru; Kanagawa, Japan
Kobayashi, Kimio; Kanagawa, Japan
Nakahata, Tatsutoshi; Kyoto, Japan
Tsuji, Koichiro; Tokyo, Japan
Habu, Sonoko; Tokyo, Japan
Koyanagi, Yoshio; Chiba, Japan
Yamamoto, Naoki; Tokyo, Japan
Sugamura, Kazuo; Miyagi, Japan
Ando, Kiyoshi; Kanagawa, Japan
Nomura, Tatsuji; Tokyo, Japan
Summary:Described herein is an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells. Further disclosed are the techniques by which such a mouse is obtained through backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor gamma-chain gene-knockout mouse with the backcrossed mouse. Therapeutic applications are included such as in the production of human antibodies and the establishment of a stem cell assay system, as well as in tumor and virus-infection models.
Abstract:The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor γ-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
US Patent Website:Click Here for Full Text of Patent
Title Number:US7145055
Application Number:US2001000221549
Date Filed:25/10/2001
Date Published:05/12/2006
Assignee:Central Institute for Experimental Animals, Kanagawa, Japan


 
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